Synthesis, Characterization, and in Vivo Biological Evaluation of Novel Benzimidazoles as Potential Anticancer Agents
نویسندگان
چکیده
Objective: Cancer is one of the major causes of death worldwide irrespective of the sex. The aim of the study was to design, synthesize, and identification of novel anti-proliferative agents that can potently target cancer. Methods: We are reporting the synthesis of the new series of N-substituted 2-(2-butyl-4-chloro-1H-imidazole-5-yl)-1H-benzo[d]imidazole derivatives and evaluated for their anti-tumor activity against HeLa cell lines. We identified the lead compound in the series and tested its anti-proliferative and anti-angiogenic properties against Ehrlich ascites tumor (EAT) bearing mice. Results: We identified 2-(2-butyl-4-chloro-1-heptyl-1H-imidazol-5yl)-1H-benzo[d]imidazole as a lead compound with the inhibitory concentration 50% of 25.3 μM. The lead compound significantly decreases the angiogenesis in peritoneum of EAT bearing mice. Conclusion: Our results clearly demonstrate that benzimidazoles suppress the cell proliferation, peritoneal angiogenesis, and ascites volume.
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